omega-necro-bump! this was my issue too! modlist was long and worked except for as described. I'd get a flicker and then many script-based keystrokes would cease to be registered with their scripts. e.g. 
	 
	Immersive Minimap II which uses AB Script hook 
	 
	SSM (simple slow motion) which uses ScriptHookRDR@DotNet-V2
 
	 
 
	turns out I was using ThirteenAG's Ultimate-ASI-Loader which I found in pinned comment on kepmehz's nexus here 
	 
 
	This caused me a PILE of needless binary search removals in a row until I was close to down to just these problem mods. 
	 
	All other script-based keystrokes also stopped working probably, just these were the ones I instantly noticed. now it works, oh happy day. modding is great when it's great and just as bad when it's bad.  
	Asi's 
	------- 
	AmbientRandomEvents.asi 
	Banking.asi 
	Boats.asi 
	Bountydialogues.asi 
	BucketWash.asi 
	CampAnywhere.asi 
	CampfireWeaponLocker.asi 
	CollectablesInRange.asi 
	Companion.asi 
	Contracts.asi 
	CutVoicelineRestoration.asi 
	DisableCameraShake.asi 
	DisableHorseHolstering.asi 
	DogComapnion.asi 
	DragPeds_Natural.asi 
	DumpThatCargo1.1.asi 
	EarlyFishing1.0.asi 
	EquineDucking.asi 
	Fisherman.asi 
	FishingRodGripToggle.asi 
	GatlingWagons.asi 
	Graves.asi 
	GunTricks.asi 
	HatBlip2.0.asi 
	horseLantern.asi 
	HorseLoadout.asi 
	Houses.asi 
	HuntingCamp.asi 
	InteractionTargetMarker.asi 
	LOS Enemy Blips.asi 
	Minimap.asi 
	MoreZoomWhileAiming.asi 
	NativeTrainer.asi 
	NoBulletTrail.asi 
	NoDeadEyeEffects.asi 
	NoHitmarker.asi 
	NoHonorLossForLawAnimals.asi 
	NoInvisibleSnipers.asi 
	NoReticleSpread.asi 
	NoWeaponDegradation.asi 
	Pay.asi 
	PedDamageOverhaul.asi 
	PredatorsRework.asi 
	QuickDraw.asi 
	RDR2.asi 
	RemoveSpeedLimits.asi 
	RestoredCutContent-Quiver1.6.6.asi 
	SafeShopping.asi 
	ScriptHookRDRDotNet.asi 
	ShoveInsteadTackle.asi 
	StashThatLantern2.8.asi 
	TieYourLasso.asi 
	vfs.asi 
	WalkingControlComplete.asi 
	 
	LML 
	------- 
	25% Faster Holstering Unholstering 
	4.75 (RDR2 scale 5.1) 
	7.5 (RDR2 scale 7.85) 
	Actually Long Long Barrels 
	Ambient Gang - RDR1 Gang 
	ambient gangs + realistic loadouts patch 
	animations 
	Best_TAA_and_Visual_Effects 
	beta douglas fir 
	Better Camera 
	better-pumps 
	bountyhunterDEI 
	ChapterVideos 
	CleanHorse 
	Coat Physics Fixes 
	CompsonsPistol 
	Corpse Spawn Distance 
	cowhandFix 
	Cut Content Dogs Unlocked for SP 
	Deputy's Badge - Merge 
	Detach 
	Disabled all map culling 
	DWW Soundtrack v1.1 
	easier_gold 
	EquineDucking 
	EXTRA_LITE_Multiplayer Asset Enabler 
	FastMapZoom 
	FirstPersonFOVMod 
	Floating Horseshoe Fix + Placeholder Posters Fix 
	Gameplay 
	Graphical issue fixes 
	Herbalist 
	HideOnlineButton 
	Higher Res Ui 
	Higher Resolution Vegetation 
	Horse Animation Fix 
	Horse Eye Draw Distance Fix 
	Horse Overhaul Mod 1.03.23532 
	Horse Overhaul Mod Compendium and Challenge Fix 
	HORSE_LITE_Multiplayer_Asset_Enabler 
	Hovering gun fix 
	ImprovementsInBlood 
	JailBreak Fix 
	Javier Poster Fix 
	JM R&E 
	JustFuckingBleed 
	JustUseTheCrossAlready 
	Legendary Channel Catfish Restored 
	lodscale 1.75-2.0 
	Longer Girthier Springfield 
	M91 Carcano 
	Model Fixes 
	mods.xml 
	movies_0 
	No More Medals in Notifications (Black) 
	No Police Whistle Sound 
	No_More_Grindy_Challenges 
	Online Bears Unlocked for SP 
	Patch (ambientpedmodelsets.meta) 
	Patch (goals_sp.meta) 
	Patch (metapeds.ymt) 
	Patch (systemsettings.ymt) 
	Patch (timecycle_mods_1-2.xml) 
	Patch (visualsettings.dat) 
	patterns.dat 
	PDO v2.0 Extended Features 
	Ped Accuracy Fix 
	Period Accurate Currency 
	PhysicalWorldMaps 
	QoL - Artie and Johnny 
	R.W.A.O 
	Real Catalog Rework 
	RealisticStDenisSchedule 
	Realistic_Loadouts v2.4 for Ambient Gang 
	Refitted Bandoliers - Shirts and Vests 
	replace 
	Sheriff Dialogue Restored 
	shutupalready 
	SkyVideos 
	Smaller DBS 
	Snappy.UI 
	stream 
	Stutter Fix 
	Terrain Textures Overhaul 
	Terrain Textures Overhaul - South 
	Textures 
	Ultra Realistic Live Leak Ragdolls 
	Uniform_Fix 
	VESTIGIA 
	VFX 
	W.E.R.O 
	WhyEm's Particles 
	Wickiup POI - Working Minimap 
	Wrong Angus Bull Fix